О. Я. Лукашив

Тернопольский национальный педагогический университет имени Владимира Гнатюка

ИСПОЛЬЗОВАНИЕ БИОЛОГИЧЕСКИ АКТИВНЫХ ВЕЩЕСТВ ДЛЯ ПРОФИЛАКТИКИ И РЕГУЛЯЦИИ МЕТАБОЛИЗМА ПРИ САХАРНОМ ДИАБЕТЕ

В статье проанализированы и обобщены современные сведения о возможностях и перспективах использования биологически активных веществ для профилактики и компенсации проявлений нарушенного обмена веществ при сахарном диабете. Освещены преимущества использования биологически активных веществ из водорослей при комплексном введении с химиотерапевтическими препаратами для лечения данного заболевания. Изучены возможности использования микроводорослей для получения селенхромсодержащих органических соединений, которые способны компенсировать проявления нарушенного метаболизма при сахарном диабете и его осложнениях, а также удовлетворить потребности человеческого организма в биологически активных веществах.

Ключевые слова: биологически активные вещества, сахарный диабет, инсулинорезистентность, глюкоза, селен, хром, водоросли

O. Jа. Lukashiv

Volodymyr Hnatiuk Ternopil National Pedagogical University, Ukraine

USING BIOLOGICALLY ACTIVE SUBSTANCES FOR THE PREVENTION AND REGULATION OF METABOLISM IN DIABETES

The article analyzes and summarizes current information on the possibilities and prospects of biologically active substances for the prevention and compensation manifestations of impaired metabolism in diabetes. Described aspects of pharmaceutical development and standardization of preparations of biologically active substances of plant, animal and mineral origin, derived from natural products. The benefits of natural compounds on chemicals, particularly the benefits of using biologically active substances from seaweed plants that have low toxicity, are soft, can be used for a long time in combination with diet and chemotherapy. Algae are a source of biologically active substances (polyunsaturated fatty acids, derivatives of chlorophyll, polysaccharides, fucoidas, glucans, pectins, galactans, alginic acids, vitamins, amino acids, proteins, enzymes, plant sterols, carotenoids, trace elements), most of which are characterized by antidiabetic effect. The basis of the healing properties of marine algae lies in their biochemical composition, which can prevent the development of diabetes, compensate for manifestations of impaired metabolism in diabetes and its complications. Biologically active algae compounds have antioxidant properties (vitamins A, E, C, B, bioflavonoids, Se), as well as can absorb and accumulate exogenous microelements, including them, in particular, pigments, proteins and lipids. The possibility of using microalgae for the production of selenium-chromium-containing organic compounds that are able to compensate for manifestations of impaired metabolism in diabetes mellitus and its complications, as well as to meet the needs of the human body in biologically active substances has been studied. Due to insufficient supply of chromium in the body there are metabolic disorders, which are similar to those observed in diabetes. Chromium plays an important role in maintaining normal levels of glucose in the blood, decreasing the levels of cholesterol, and in combination with selenium - inhibits the development of oxidative stress. It was investigated that Cr3+ exhibits antioxidant properties, while decreasing the secretion of tumor necrosis factor-α, oxidative stress and peroxidation of lipids at high glucose and H2O2 levels in monocyte cultures of U937 cells.

Keywords: biologically active substances, diabetes, insulin resistance, glucose, selenium, chromium, algae