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journals.chem-bio.com.ua

H.I. FALFUSHYNSKA, L.L. GNATYSHYNA, I.V. YURCHAK, O.B. STOLIAR

Volodymyr Hnatiuk Ternopil National Pedagogical University, Ukraine, I.Ya. Horbachevsky Ternopil State Medical University

Despite metal-contained nanoparticles (n) represent novel kind of environmental pollution, their toxicity to aquatic habitats is unclear with regards to multiple stress exposures. In present study, male Unio tumidus were exposed for 14 days to n-ZnO (3.1 μM), Zn2+ (3.1 μM), Ca-channel blocker nifedipine (Nfd, 10 μM), combinations of n-ZnO and Nfd or n-ZnO and thiocarbamate fungicide Tattoo (Ta, 91 µg L−1) at 18oC, and n-ZnO at 25oC. Activities of vitellogenesis (Vtg), stress and detoxification systems (Mn- and Cu,Zn-superoxide dismutase, metallothionein (MT), EROD), nuclear lesions (NL) and choline esterase (ChE) activity) were analysed. Vtg and NL were elevated in most exposures. N-ZnO per se did not provoke any other changes of indices unlike Zn. In combine exposures, the activation of stress-responses, EROD and phenoloxidase activities were detected. Nfd caused the most prominent modulations of n-ZnO effect on Vtg and MT. Only Zn and Nfd caused ChE depletion.

Keywords: bivalve mollusk, zinc nanooxide, heating, nifedipine, thiocarbamate, combine exposure, biomarker

Опубліковано в 2015. - № 3-4 (64)

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